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Tired of making excuses for my life outcomes

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Joseph Rivera
Joseph Rivera

OMNI VAN V1.0 1.36.X


We applied partitioned linkage disequilibrium (LD) score regression using LDSC48 (v1.0.1) to perform enrichment analysis using the expanded mCA GWAS summary statistics, in combination with tissue-specific epigenetic and transcriptomic functionality annotations from GenoSkyline-Plus22. In addition to the baseline annotations for diverse genomic features as suggested in the LDSC user manual, we specifically examined the enrichment signals in two tiers of annotations of different resolutions: GenoSkyline-Plus functionality scores of seven broad tissue clusters (immune, brain, cardiovascular, muscle, gastrointestinal tract, epithelial, and others); and GenoSkyline-Plus functionality scores of 11 tissue and cell types in the immune cluster (listed in Fig. 6d).




OMNI VAN V1.0 1.36.X

041b061a72


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